Supplement shelves are packed with promises — fat burners, appetite suppressants, metabolism boosters — but which ones actually work? This science-backed guide cuts through the hype to reveal what current research really says about weight-loss supplements in 2026. From proven options to overhyped duds, you'll learn how each supplement works, realistic expectations for results, safety considerations, and how to avoid wasting money on ineffective products. Whether you're supplementing an existing routine or just starting out, this guide gives you the clarity to make informed, evidence-based choices — no gimmicks, no guesswork.