Resolve the Borderline Call With Confidence

The Gastrointestinal Diagnostic Pathology Handbook is a clinical reference built for the moment a biopsy does not resolve itself on first inspection. Across eighteen chapters spanning the esophagus, stomach, small intestine, colon, anus, liver, biliary tract, and pancreas, it develops thirty-six named diagnostic discriminations, from reactive atypia versus dysplasia to GIST risk stratification to PTLD versus reactive lymphoid hyperplasia, each resolved through one framework: the pattern, the mimics to exclude, the test that settles it, and the finding that locks the diagnosis. Written for residents, GI pathology fellows, and AP board candidates, it is grounded in current diagnostic criteria and immunohistochemical panels.

Every chapter closes with the same discriminating structure it opens with, so the reasoning stays available as a working reference at the scope, in clinic, or on call.

Inside, you will find:
• Barrett esophagus and colitis dysplasia grading — apply the surface-maturation principle separating reactive change from true dysplasia
• MALT lymphoma, DLBCL, and rare GI lymphoma subtyping — confirm diagnosis with the exact immunohistochemical panel each entity requires
• GIST diagnosis and site-specific risk stratification — distinguish GIST from leiomyoma and schwannoma, then apply the risk tables guiding adjuvant therapy
• Pancreatic ductal adenocarcinoma versus chronic pancreatitis — resolve this difficult discrimination using perineural invasion and nuclear size variation
• Hepatocellular carcinoma versus benign hepatocellular lesion — apply reticulin staining and the glypican-3/HSP70/glutamine synthetase panel
• IPMN, mucinous cystic neoplasm, and serous cystadenoma — apply the required diagnostic criteria separating three cystic neoplasms of very different risk
• Acute GVHD and PTLD in the transplant patient — correlate apoptosis grading with engraftment timing and confirm PTLD with the correct workup
• The GI Diagnostic Confidence Atlas — every discrimination indexed by chapter, ancillary test, and clinical scenario for rapid lookup

Add this handbook to your reference shelf and turn the next borderline case into a confident, defensible diagnosis.