This book includes selected papers presented at the International Conference on Data Processing and Networking (ICDPN 2025), organized by Institute of Technology and Business in České Budějovice, Near Prague, Czech Republic, during 7 – 8 November 2025. It covers up-to-date cutting-edge research on big data processing and analytics, data mining and machine learning, artificial intelligence and deep learning, wireless, mobile, and ad hoc networks, network security and privacy, internet of things (IOT) and sensor networks, data communication, and computer vision and image processing.